Fresh analysis indicates that individuals who stop using popular slimming jabs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who end conventional lifestyle programs.
Findings released in a prominent medical journal shows that while obese people can lose about a fifth of their total mass while using the jabs, the mass is regained at an average rate of 0.8 kg per month upon discontinuation.
"Individuals buying such treatments should be informed of the danger of rapid weight regain when the therapy concludes," cautioned expert Dr. Susan Jebb.
That rate of regain implies a return to starting weight within about one and a half years.
Comparing Treatments
The research, which reviewed dozens of studies involving over 9,000 of patients, contrasted the results of GLP-1 agonists with conventional dieting.
Researchers emphasize that individuals who shed pounds through diet and exercise typically see a less rapid weight regain—approximately 0.1 kg a month—once they finish.
Explaining the Rapid Rebound
Doctors believe the mode of action of the drugs is key to understanding the heightened rebound.
These medications mimic a body's own chemical called GLP-1, which controls hunger.
"Long-term administration of GLP-1 concentrations several times higher than normal may cause the body to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this GLP-1 'fix' results in appetite is no longer kept in check, making excessive eating much more probable."
A Chronic Condition?
Health authorities advise the injections for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians argue that, considering the likelihood of relapse, the treatment should be considered ongoing.
This view is echoed by drug manufacturers, who note that the findings "underscore the long-term character of excess weight," akin to managing diseases like diabetes.
Patient Experiences
Users who have stopped the medication explain a powerful return of appetite.
"I experienced a trigger that goes on and you're instantly extremely hungry," described one woman.
The struggle is compounded if users have not adopted permanent dietary or behavioural changes during therapy.
Significant Interest
Recent estimates suggest that a significant number of people in the UK have tried these injections in the past year, with demand being substantial.
- Adoption is more common among females compared to men.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the medications through private healthcare rather than public health services.
Ultimately, experts emphasize that while these medications are effective tools for shedding pounds, they are not a permanent cure and maintained weight loss hinges on ongoing lifestyle management.
